[ effects of hydro-alcoholic extracts of aerial components of Teucrium polium on pressure ulcer healing process and tensile strength in Wistar rats]

Wound healing represents a dynamic physiological process influenced by many factors. The aim of the present study was to evaluate the effects of hydro-alcoholic extracts of aerial components of Teucrium polium on the tensile strength in rat. Twelve Wistar rats were randomly divided into two equal [n= 6] treatment and control groups, pressure ulcer were made over the dorsal thoracic region according to the shyn model. Animals were treated with topical hydro-alcoholic extracts of aerial components of Teucrium polium twice a day post surgery until complete healing was achieved. Tensiometry were then studied. No significant difference in biomechanical parameters was observed among the ointment containing of extract 1%, vehicle and control groups. This study shows that topical application of Teucrium polium. Aerial components of Teucrium polium did not have any effect on healing of pressure ulcer in an animal model. Further studies are requiring for assessment of other extracts by different solvents of this plant on pressure ulcer wound healing

effects of pentoxifylline on the wound healing process in a rat experimental pressure sore model

The present study used a histological evaluation method to examine the effects of pentoxifylline [PTX] on healing an experimentally-induced pressure sore in a rat model. There were 36 adult male rats used in this study. Under general anesthesia and sterile conditions, we used forceps to create one pressure sore on each rat. A double layer of folded skin from the dorsal region was held with the highest forceps pressure grade for two hours, followed by 30 minutes of relaxation. This was repeated 12 times over three consecutive working days, and created a pressure sore after seven days. Next, rats were randomly divided into three control and three experimental groups. The experimental groups received intraperitoneal injections of PTX [50 mg/kg] for 14, 21, and 28 days after the pressure sore was created. Control groups received a similar volume of saline solution. Rats were euthanized, after which samples were extracted from the wound area and prepared for light microscopy examination. We calculated the number of neutrophils, macrophages, fibroblasts, blood vessel sections, and thicknesses of the newly formed epidermis and dermis. Although the values of some studied parameters were higher in the experimental group, there were no significant differences noted between the experimental and control groups. In this study PTX did not increase any histological parameters. Thus, the effects of PTX on the pressure sore model seem to result from different mechanisms

A comparative study of the effects of topical application of Aloe vera, thyroid hormone and silver sulfadiazine on skin wounds in Wistar rats / 한국실험동물학회지

Many research studies report the healing effects of Aloe Vera, thyroid hormone cream and silver sulfadiazine. However, the effects of these therapeutic agents are not well understood and have not been compared in one study. This study aimed at investigating the effects of topical application of an Aloe vera gel, a thyroid hormone cream and a silver sulfadiazine cream on the healing of skin wounds surgically induced in Wistar rats for determining the treatment of choice. In a randomized controlled trial, twelve male rats, aged 120 days and with a mean weight of 250 to 300 g, were divided randomly into 5 groups based on drug treatments: Aloe vera gel (AV), thyroid hormone cream (TC), silver sulfadiazine 1% (S), vehicle (V) and control. To evaluate the efficacy of each treatment technique, a biomechanical approach was used to assess tensile stress after 14 days of treatment. Tensile stress was significantly improved in the Aloe vera gel group as compared with the other four groups (P< or =0.05). While the other treatment options resulted in better healing than the control group, this difference was not significant. We conclude that Aloe vera topical application accelerated the healing process more than thyroid hormone, silver sulfadiazine and vehicle in surgically induced incisions in rats.

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats / 대한해부학회지

Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P< or =0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.